A shortcut to a skeletal muscle DHPR knock-in?
نویسندگان
چکیده
منابع مشابه
DHPR activation underlies SR Ca release induced by osmotic stress in isolated rat skeletal muscle fibers
Skeletal muscle swells as a consequence of intense activity and gradually returns to its original volume after cessation of exercise (Sjogaard et al., 1985; Peeze Binkhorst et al., 1990; Watson et al., 1993; Raja et al., 2006). Swelling occurs due to an accumulation of metabolites within the cytosol and a consequent increase in osmolarity, which drives the entry of water from the extracellular ...
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Changes in skeletal muscle volume induce localized sarcoplasmic reticulum (SR) Ca(2+) release (LCR) events, which are sustained for many minutes, suggesting a possible signaling role in plasticity or pathology. However, the mechanism by which cell volume influences SR Ca(2+) release is uncertain. In the present study, rat flexor digitorum brevis fibers were superfused with isoosmotic Tyrode's s...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2011
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2011.216234